Australian Scientists are closer to developing a blood screening test for the early detection of Alzheimer’s disease after identifying blood-based biological markers associated with the build up of a toxic protein in the brain. This protein occurs years before symptoms appear and irreversible brain damage occurs.
Dr Samantha Burnham from the CSIRO’s Preventative Health Flagship said; “Early detection is critical if we are to make any real difference in the battle against Alzheimer’s, giving those at risk a much better chance of receiving treatment earlier, before it’s too late to do much about it”.
Sophisticated mathematical models were used to analyse data from 273 participants in the Australian Imaging, Biomarkers and Lifestyle study of ageing (AIBL). This identified nine markers that correlate with brain positron emission tomography (PET) imaging measurements of a toxic protein, amyloid beta, which deposits in the brain as plaques early in disease development.
“The progressive build up of the toxic protein, amyloid beta, is one of the earliest changes in the brain associated with the development of Alzheimer’s disease,” said Dr Noel Faux, from the Florey Institute for Neuroscience and Mental Health.
“A recent study from the AIBL team showed that amyloid beta levels become abnormal about 17 years before dementia symptoms appear. This gives us a much longer time to intervene to try to slow disease progression if we are able to detect cases early.”
Dr Burnham adds “We hope our continued research will lead to the development of a low cost, minimally invasive population based screening test for Alzheimer’s.”
“A blood test would be the ideal first stage to help identify many more people at risk before a diagnosis is confirmed with cognitive tests and PET imaging or cerebral spinal fluid (CSF) testing.”
The results have been published in the journal Molecular Psychiatry.